Synlett 2023; 34(05): 488-492
DOI: 10.1055/a-2000-0442
letter

MoS2-Catalyzed Aerobic Synthesis of Tetraethylthiuram Disulfide in Batch and Continuous Flow

Ze-Run Zhao
,
Hao-Xing Xu
,
Xiao Wang

We thank the support of National Natural Science Foundation of China (Grant No. 21872068) and Technology Innovation Fund of Nanjing University (Grant No. 020514807001).


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Abstract:

Tetraethylthiuram disulfide (TETD) is one of the most important thiuram-class rubber vulcanization accelerators and a ‘star molecule’ in other areas. The development of a mild, efficient, low-cost, safe, and sustainable approach to produce TETD is extremely desirable. Here, we developed a much-improved route to synthesize TETD using MoS2 as the catalyst and ethanol as the solvent. A packed-bed microflow strategy was implemented to accelerate the catalytic process. TETD was obtained with an excellent yield and purity within a short residence time. Besides, this continuous process did not generate any waste salts, rendering it a sustainable method for producing thiuram-type compounds.

Supporting Information



Publication History

Received: 25 October 2022

Accepted after revision: 16 December 2022

Accepted Manuscript online:
16 December 2022

Article published online:
13 January 2023

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